Journal
NANO LETTERS
Volume 7, Issue 7, Pages 1929-1934Publisher
AMER CHEMICAL SOC
DOI: 10.1021/nl070610y
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Funding
- NCI NIH HHS [5R01CA109385] Funding Source: Medline
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Metal nanoshells are core/shell nanoparticles that can be designed to either strongly absorb or scatter within the near-infrared (NIR) wavelength region (similar to 650-950 nm). Nanoshells were designed that possess both absorption and scattering properties in the NIR to provide optical contrast for improved diagnostic imaging and, at higher light intensity, rapid heating for photothermal therapy. Using these in a mouse model, we have demonstrated dramatic contrast enhancement for optical coherence tomography (OCT) and effective photothermal ablation of tumors.
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