Journal
EXPERIMENTAL NEUROLOGY
Volume 206, Issue 1, Pages 95-100Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.expneurol.2007.04.002
Keywords
estradiol; angiogenesis; stroke; infarct; penumbra; rat
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Funding
- NINDS NIH HHS [K08 NS050167, K08 NS050167-04] Funding Source: Medline
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Peri-infarct increase of vascular density has been observed in animals and in humans with ischemic stroke. Increased peri-infarct vascular density correlates with improved functional outcome after stroke. We hypothesized that pre-treatment with estradiol will increase post-ischemic peri-infarct capillary density in a rat model of transient ischemic stroke. Estradiol, compared to placebo, augmented post-ischemic peri-infarct vascular density by 22% 10 days after stroke. Recovery of forelimb function was not improved with estradiol treatment on day three and nine poststroke. Loss of estradiol may limit repair in the peri-infarct region by limiting angiogenesis, but functional significance in stroke recovery requires further investigation. (C)) 2007 Elsevier Inc. All rights reserved.
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