Journal
ANALYTICAL CHEMISTRY
Volume 84, Issue 7, Pages 3403-3409Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ac300217p
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Continuous glucose measurement has improved the treatment of type 1 diabetes and is typically provided by externally powered transcutaneous amperometric sensors. Self-powered glucose sensors (SPGSs) could provide an improvement over these conventionally powered devices, especially for fully implanted long-term applications where implanted power sources are problematic. Toward this end, we describe a robust SPGS that may be built from four simple components: (1) a low-potential, wired glucose oxidise anode; (2) a Pt/C cathode; (3) an overlying glucose flux-limiting membrane; and (4) a resistor bridging the anode and cathode. In vitro evaluation showed that the sensor output is linear over physiologic glucose concentrations (2-30 mM), even at low O-2 concentrations. Output was independent of the connecting resistor values over the range from 0 to 10 M Omega. The output was also stable over 60 days of continuous in vitro operation at 37 degrees C in 30 mM glucose. A 5-day trial in a volunteer demonstrated that the performance of the device was virtually identical to that of a conventional amperometric sensor. Thus, this conventionally powered devices, especially for fully implanted long-term applications.
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