Journal
JOURNAL OF MEDICAL VIROLOGY
Volume 79, Issue 7, Pages 927-930Publisher
WILEY
DOI: 10.1002/jmv.20869
Keywords
hepatitis E virus; HEV; seroprevalence; non-A; non-B; non-C hepatitis; anti-HEV antibodies; Hungary
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Many cases of acute hepatitis remain undiagnosed and the hepatitis E virus (HEV) is emerging in industrialized countries. The aim of this study was to assess the role HEV as causative agent in acute non-A, non-B, and non-C hepatitis patients in Hungary. 10.5% of the 264 acute non-A, non-B, and non-C hepatitis patients tested had anti-HEV IgG and 1.9% had anti-HEV IgM as tested by ELISA. After confirmation by Western blot 6.1% of the acute non-A, non-B, and non-C hepatitis patients had anti-HEV IgG antibodies only and 1.1% of the patients had both IgG and IgM. All 19 patients that were positive for anti-HEV 19G and/ or IgM tested negative for HEV RNA by PCR. Only a small proportion of the acute hepatitis cases in the southwest of Hungary are assumed to be attributed to HEV infection, however, hepatitis should be considered along with hepatitis A, B, and C in the diagnosis of acute hepatitis.
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