Journal
ANALYTICAL CHEMISTRY
Volume 84, Issue 22, Pages 9679-9683Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ac302634u
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Funding
- Australian Postgraduate Awards
- Australian Research Council (ARC) LIEF program [LE0989078]
- ARC Centre of Excellence for Free Radical Chemistry and Biotechnology [CE0561607]
- ARC Centre of Excellence for Electromaterials Science [CE0561616]
- ARC [FT110100249, FT0990846]
- Australian Research Council [LE0989078, FT0990846] Funding Source: Australian Research Council
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The on-demand printing of living cells using inkjet technologies has recently been demonstrated and allows for the controlled deposition of cells in microarrays. Here, we show that such arrays can be interrogated directly by robot-controlled liquid microextraction coupled with chip-based nanoelectospray mass spectrometry. Such automated analyses generate a profile of abundant membrane lipids that are characteristic of cell type. Significantly, the spatial control in both deposition and extraction steps combined with the sensitivity of the mass spectrometric detection allows for robust molecular profiling of individual cells.
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