Journal
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
Volume 293, Issue 1, Pages E228-E236Publisher
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/ajpendo.00479.2006
Keywords
insulin secretion; islets of Langerhans; type 2 diabetes mellitus
Categories
Funding
- NHLBI NIH HHS [HL-075080] Funding Source: Medline
- NIDCR NIH HHS [P20 RR/DE-17702] Funding Source: Medline
- NIDDK NIH HHS [1R01 DK-077624-01] Funding Source: Medline
Ask authors/readers for more resources
It has been shown that maternal diabetes increases the risk for obesity, glucose intolerance, and Type 2 diabetes mellitus in the adult life of the offspring. Mechanisms for these effects on the offspring are not well understood, and little information is available to reveal the mechanisms. We studied the effect of maternal diabetes on P-cell function in the offspring of streptozotocin (STZ)-induced diabetic rat mothers (STZ-offspring). STZ-offspring did not become glucose intolerant up to 15 wk of age. At this age, however, insulin secretion was significantly impaired, as measured by in vivo and in vitro studies. Consistent with these changes, islet glucose metabolism and some important glucose metabolic enzyme activities were reduced. No significant changes were found in islet morphological analysis. These data indicate that P-cell function is impaired in adult STZ-offspring; these changes may contribute to the development of type 2 diabetes mellitus in adulthood.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available