Journal
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
Volume 43, Issue 1, Pages 1-10Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.yjmcc.2007.04.005
Keywords
KLF; Kruppel; cardiomyocyte; heart; smooth muscle; myocyte; skeletal; transcription
Categories
Funding
- NHLBI NIH HHS [R01 HL072952-05, R01 HL075427-05, R01 HL086548-02, R01 HL084154-02, R01 HL072952, R01 HL076754, R01 HL086548, R01 HL075427, R01 HL076754-04, R01 HL084154] Funding Source: Medline
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The Kruppel-like Factor (KLF) family of zinc-finger transcription factors are critical regulators of cell differentiation, phenotypic modulation and physiologic function. An emerging body of evidence implicates an important role for these factors in cardiovascular biology, however, the role of KLFs in Muscle biology is only beginning to be understood. This article reviews the published data describing the role of KLFs in the heart, smooth muscle, and skeletal muscle and highlights the importance of these factors in cardiovascular development, physiology and disease pathobiology. (C) 2007 Elsevier Inc. All rights reserved.
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