Journal
JOURNAL OF PEPTIDE SCIENCE
Volume 13, Issue 7, Pages 493-497Publisher
WILEY
DOI: 10.1002/psc.874
Keywords
nanoparticles; suspension; solid-phase synthesis; peptide synthesis in water
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Solid-phase peptide synthesis has many advantages compared with solution peptide synthesis. However, this procedure requires a large amount of organic solvents. Since safe organic solvent waste disposal is an important environmental problem, a technology based on coupling reaction of suspended nanoparticle reactants in water was studied. Fmoc-amino acids are used widely, but most of them show low solubility in water. We prepared well-dispersible Fmoc-amino acid nanoparticles in water by pulverization using a planetary ball mill in the presence of poly(ethylene glycol). Leu-enkephalin amide was prepared successfully using the nanoparticulate Fmoc-amino acid on a poly(ethylene glycoll-grafted Rink amide resin in water. Copyright (C) 2007 European Peptide Society and John Wiley & Song, Ltd.
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