Journal
CELLULAR IMMUNOLOGY
Volume 248, Issue 1, Pages 4-11Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.cellimm.2007.03.009
Keywords
ischemia; T cells; inflammation
Categories
Funding
- NIDDK NIH HHS [R01 DK054770-07, R01 DK054770] Funding Source: Medline
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The pathogenesis of ischemia-reperfusion injury (IRI) is complex and not well understood. Inflammation plays an important role in IRI, with involvement of leukocytes, adhesion molecules, chemokines and cytokines. Emerging data suggest a role of T cells as mediators of IRI both in renal and extra-renal organs. Divergent roles of T cell subsets have also been elucidated, suggesting a more complicated role of T cells in the different phases of IRI This review presents recent evidence from various animal models that advances our understanding of the role T cells play in IRI These findings entertain the possibility of using immunotherapeutic agents for the prevention and treatment of IRI (C) 2007 Elsevier Inc. All rights reserved.
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