Journal
NATURE REVIEWS DRUG DISCOVERY
Volume 6, Issue 7, Pages 556-568Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrd2355
Keywords
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Funding
- Cancer Research UK [A8363] Funding Source: Medline
- Breast Cancer Now [BREAST CANCER NOW RESEARCH CENTRE] Funding Source: Medline
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With the development of RNA interference (RNAi) libraries, systematic and cost-effective genome-wide loss-of-function screens can now be carried out with the aim of assessing the role of specific genes in neoplastic phenotypes, and the rapid identification of novel drug targets. Here, we discuss the existing applications of RNAi in cancer drug discovery and highlight areas in this process that may benefit from this technology in the future.
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