Journal
ANALYTICAL CHEMISTRY
Volume 83, Issue 7, Pages 2605-2612Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ac200432c
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Funding
- Science and Engineering Research Council [102 152 0014]
- Academic Research Funding Tier 1 of Singapore [RG65/08]
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Here, we present a mean to expand the use of individual metallic nanoparticles to two-dimensional plasmonic nanoarrays. An optical detection platform to track down localized surface plasmon resonance (LSPR) signals of individual nanoparticles on substrates was built for the application of plasmonic nanoarrays. A pseudoimage of nanoparticles on a substrate was reconstructed from their scattering spectra obtained by scanning a user-defined area. The spectral and spatial resolutions of the system were also discussed in detail. Most importantly, we present a method to normalize the localized surface plasmon resonance from geometrically different nanoparticles. After normalization, plasmonic responses from different particles become highly consistent, creating well-fitted dose response curves of both surrounding refractive index changes and receptor analyte binding to the surface of individual nanoparticles. Finally, the proof-of-concept system for plasmonic nanoarray detection is demonstrated by the measurement of the aptamer thrombin binding event.
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