4.8 Article

Nanostructure-Initiator Mass Spectrometry Metabolite Analysis and Imaging

Journal

ANALYTICAL CHEMISTRY
Volume 83, Issue 1, Pages 2-7

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ac101565f

Keywords

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Funding

  1. California Institute of Regenerative Medicine [TR1-01219]
  2. National Institutes of Health [R24 EY017540-04, P30 MH062261-10, P01 DA026146-02]
  3. NIH/NIA [L30 AG0 038036]
  4. Department of Energy [FG02-07ER64325, DE-AC0205CH11231]
  5. NATIONAL EYE INSTITUTE [R24EY017540] Funding Source: NIH RePORTER
  6. NATIONAL INSTITUTE OF MENTAL HEALTH [P30MH062261] Funding Source: NIH RePORTER
  7. NATIONAL INSTITUTE ON DRUG ABUSE [P01DA026146] Funding Source: NIH RePORTER

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Nanostructure-Initiator Mass Spectrometry (NIMS) is a matrix-free desorption/ionization approach that is particularly well-suited for unbiased (untargeted) metabolomics. An overview of the NIMS technology and its application in the detection of biofluid and tissue metabolites are presented. (To listen to a podcast about this feature, please go to the Analytical Chemistry multimedia page at pubs.acs.org/page/ancham/audio/index.httnl.)

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