Journal
ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS
Volume 63, Issue -, Pages 602-604Publisher
INT UNION CRYSTALLOGRAPHY
DOI: 10.1107/S1744309107028783
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Tau-tubulin kinase 2 (TTBK2) is a Ser/Thr kinase that putatively phosphorylates residues Ser208 and Ser210 ( numbered according to a 441-residue human tau isoform) in tau protein. Functional analyses revealed that a recombinant kinase domain ( residues 1-331) of human TTBK2 expressed in insect cells with a baculovirus overexpression system retains kinase activity for tau protein. The kinase domain of TTBK2 was crystallized using the hanging- drop vapour-diffusion method. The crystals belong to space group P2(1)2(1)2(1), with unit-cell parameters a = 55.6, b = 113.7, c = 117.3 angstrom, alpha = beta = gamma = 90.0 degrees. Diffraction data were collected to 2.9 angstrom resolution using synchrotron radiation at BL24XU of SPring-8.
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