Journal
ANALYTICAL CHEMISTRY
Volume 84, Issue 1, Pages 17-20Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ac202301k
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Funding
- NIH [1R01 CA 113746, 1R01 CA 132034]
- NSF [DMR 1005011, CBET 0959422]
- Division Of Materials Research
- Direct For Mathematical & Physical Scien [1005011] Funding Source: National Science Foundation
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Using water-soluble, fluorescent, flexible polymers, we have devised a novel methodology for identification and differentiation of prostate cancer cells. Using a stepwise linear discriminant analysis, we demonstrate that the differential modulations of the polymer emission intensities in the presence of conditioned cell culture media can be used to distinguish between prostate cancer subtypes and between cancerous and noncancer cells. The differences in the compositions of the conditioned cell culture media are likely contributing to different fluorescence spectral patterns of the polymers. This in vitro approach may provide a novel platform for the development of an alternative prostate cancer diagnostic and subtyping technique.
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