Journal
CELLULAR AND MOLECULAR LIFE SCIENCES
Volume 64, Issue 14, Pages 1739-1751Publisher
SPRINGER BASEL AG
DOI: 10.1007/s00018-007-7053-7
Keywords
pathway; pathway database; biological networks; information system; networks biology; drug discovery; integration
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The biological system is a complex physicochemical system consisting of numerous dynamic networks of biochemical reactions and signaling interactions between cellular components. This complexity makes it virtually unanalyzable by traditional methods. Hence, biological networks have been developed as a platform for integrating information from high- to low-throughput experiments for analysis of biological systems. The network analysis approach is vital for successful quantitative modeling of biological systems. The numerous online pathway databases vary widely in coverage and representation of biological processes. An integrated network-based information system for querying, visualization and analysis promised successful integration of data on a large scale. Such integrated systems will greatly facilitate the understanding of biological interactions and experimental verification.
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