Journal
JOURNAL OF LEUKOCYTE BIOLOGY
Volume 82, Issue 1, Pages 16-32Publisher
WILEY
DOI: 10.1189/jlb.0107051
Keywords
beta-arrestin; heterotrimeric; immune; Toll-like receptor; kinase; inflammation
Categories
Ask authors/readers for more resources
G-protein-coupled receptors (GPCRs) are widely targeted in drug discovery. As macrophages are key cellular mediators of acute and chronic inflammation, we review here the role of GPCRs in regulating macrophage function, with a focus on contribution to disease pathology and potential therapeutic applications. Within this analysis, we highlight novel GPCRs with a macrophagerestricted expression profile, which provide avenues for further exploration. We also review an emerging literature, which documents novel roles for GPCR signaling components in GFCR-independent signaling in macrophages. In particular, we examine the crosstalk between GPCR and TLR signaling pathways and highlight GPCR signaling molecules which are likely to have uncharacterized functions in this cell lineage.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available