Journal
JOURNAL OF CELLULAR BIOCHEMISTRY
Volume 101, Issue 4, Pages 805-815Publisher
WILEY
DOI: 10.1002/jcb.21159
Keywords
tumor microenvironment; tumor stroma; cancer-associated fibroblasts; neovascularization; tumor-associated inflammation; bone marrow-derived stem cells; mesenchymal stem cells
Categories
Funding
- NCI NIH HHS [1 R01 CA119061] Funding Source: Medline
Ask authors/readers for more resources
The tumor microenvironment, composed of non-cancer cells and their stroma, has become recognized as a major factor influencing the growth of cancer. The microenvironment has been implicated in the regulation of cell growth, determining metastatic potential and possibly determining location of metastatic disease, and impacting the outcome of therapy. While the stromal cells are not malignant per se, their role in supporting cancer growth is so vital to the survival of the tumor that they have become an attractive target for chemotherapeutic agents. In this review, we will discuss the various cellular and molecular components of the stromal environment, their effects on cancer cell dynamics, and the rationale and implications of targeting this environment for control of cancer. Additionally, we will emphasize the role of the bone marrow-derived cell in providing cells for the stroma.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available