Journal
JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY
Volume 29, Issue 7, Pages 500-505Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/MPH.0b013e3180959af4
Keywords
pediatrics; nasopharyngeal carcinoma; IMRT; long-term effects
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Funding
- NCI NIH HHS [CA61384, P01 CA 94237, P01 CA094237, P01 CA094237-06] Funding Source: Medline
- NCRR NIH HHS [RR00188] Funding Source: Medline
- NIDDK NIH HHS [T32 DK064717, T32 DK064717-05, T32 DK64717] Funding Source: Medline
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Background: Chemotherapy and intensity-modulated radiotherapy (IMRT) have decreased treatment-related complications in adult patients with nasopharyngeal carcinoma (NPC). Our aim was to evaluate the toxicity profile of IMRT plus chemotherapy in pediatric NPC patients. Observations: Five patients were treated with chemotherapy and IMRT. All patients experienced grade 3-4 acute toxicities. With a median follow-up of 6.3 years, all patients experienced >= 3 long-term toxicities. The most common toxicities were hypothyroidism, xerostomia, hearing loss, and dental disease. Conclusions: We did not observe a significant decrease in long-term toxicities with IMRT plus chemotherapy in our small cohort of pediatric NPC patients.
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