Journal
EUROPEAN HEART JOURNAL
Volume 28, Issue 14, Pages 1702-1708Publisher
OXFORD UNIV PRESS
DOI: 10.1093/eurheartj/ehm226
Keywords
aspirin; coronary artery disease; platelet aggregation; thromboxane
Categories
Ask authors/readers for more resources
Aims We sought to compare the results obtained from six major platelet function tests in the assessment of the prevalence of aspirin resistance in patients with stable coronary artery disease. Methods and results 201 patients with stable coronary artery disease receiving daily aspirin therapy (>= 180 mg) were recruited. Platelet aggregation was measured by: (i) light transmission aggregometry (LTA) after stimulation with 1.6 mM of arachidonic acid (AA), (ii) LTA after adenosine diphosphate (ADP) (5, 10, and 20 mu M) stimulation, (iii) whole blood aggregometry, (iv) PFA-100 (R), (v) VerifyNow Aspirin (R); urinary 11-dehydro-thromboxane B-2 concentrations were also measured. Eight patients (4%, 95% Cl 0.01-0.07) were deemed resistant to aspirin by LTA and AA. The prevalence of aspirin resistance varied according to the assay used: 10.3-51.7% for LTA using ADP as the agonist, 18.0% for whole blood aggregometry, 59.5% for PFA-100 (R), 6.7% for VerifyNow Aspirin (R), and finally, 22.9% by measuring urinary 11 -dehydro-thromboxane B-2 concentrations. Results from these tests showed poor correlation and agreement between themselves. Conclusion Platelet function tests are not equally effective in measuring aspirin's antiplatelet effect and correlate poorly amongst themselves. The clinical usefulness of the different assays to classify correctly patients as aspirin resistant remains undetermined.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available