Journal
NATURE REVIEWS CANCER
Volume 7, Issue 7, Pages 554-562Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrc2168
Keywords
-
Categories
Ask authors/readers for more resources
Protein kinase C (PKC) comprises a family of serine/ threonine kinases that are involved in the transduction of signals for cell proliferation, differentiation, apoptosis and angiogenesis. Unsurprisingly, disruption of PKC regulation is implicated in tumorigenesis and drug resistance. PKC function is complex in this context owing to the differing roles of individual isozymes within the cell and across tumour types. Therapeutically targeting PKC isozymes is not new; however, with many of the early PKC inhibitor cytotoxic drug combinations being discarded at the phase II level, and recent phase III studies in non-small-cell lung cancer proving negative, what's going wrong?
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available