Journal
ANALYTICAL CHEMISTRY
Volume 84, Issue 2, Pages 1070-1075Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ac202700x
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Funding
- Technology Strategy Board
- EPSRC
- Philips
- EPSRC [TS/G001405/1] Funding Source: UKRI
- Engineering and Physical Sciences Research Council [TS/G001405/1] Funding Source: researchfish
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This paper demonstrates an integrated microfluidic system that performs a full blood count using impedance analysis. A microfluidic network design for red blood cell (RBC) lysis is presented, and the diffusive mixing processes are analyzed using experimental and simulated results. Healthy and clinical bloods analyzed with this system, and the data shows good correlation against data obtained from commercial hematology machines. The data from the microfluidic system was compared against hospital data for 18 clinical samples, giving R-2 (coefficient of determination) values of 0.99 for lymphocytes, 0.89 for monocytes, and 0.99 for granulocytes in terms of relative counts and 0.94 for lymphocytes, 0.91 for monocytes, and 0.95 for granulocytes This demonstrates the potential clinical utility of this new system for a point-of-care purpose. in terms of absolute counts.
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