Journal
TRENDS IN PARASITOLOGY
Volume 23, Issue 7, Pages 297-299Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.pt.2007.05.001
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- Intramural NIH HHS Funding Source: Medline
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Melanization is a potent immune response mediated by phenoloxidase (PO). Multiple Clip-domain serine proteases (CLIP) regulate PO activation as part of a complex cascade of proteases that are cleaved sequentially. The role of several CLIP as key activators or suppressors of the melanization responses of Anopheles gambiae to Plasmodium berghei (murine malaria) has been established recently using a genome-wide reverse genetics approach. Important differences in regulation of PO activation between An. gambiae strains were also identified. This review summarizes these findings and discusses our current understanding of the An. gambiae melanization responses to Plasmodium.
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