Journal
JOURNAL OF SEPARATION SCIENCE
Volume 30, Issue 11, Pages 1672-1685Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/jssc.200600526
Keywords
high temperature liquid chromatography; review; theory
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High temperature liquid chromatography (HTLC) exists in a temperature region beyond ambient (ca. 40 degrees C) and below super critical temperatures. The promises of HTLC, such as increased analysis speed, enhanced separation productivity, green LC with pure water mobile phases coupled to universal FID detection, and fast analysis of complex samples by combination with fast 2-D techniques, have become an option for routine practice. The focus of this paper is to review the key developments that have made the application of HTLC a practical technique and draw attention to new developments in 2-D techniques that incorporate HTLC that offer an opportunity to vastly increase the usefulness of HPLC for the analysis of complex samples.
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