Journal
JOURNAL OF GENERAL VIROLOGY
Volume 88, Issue -, Pages 1876-1886Publisher
MICROBIOLOGY SOC
DOI: 10.1099/vir.0.82741-0
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Funding
- Medical Research Council [G9818340B] Funding Source: researchfish
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Since 'constitutive activation' Of STAT1 was first described in Epstein-Barr virus (EBV)-immortalized lymphoblastoid cell lines (LCLs), there has been controversy regarding the molecular identity of the STAT1 DNA-binding complex found in these cells. The post-translational modifications of STAT1 in LCLs have been analysed and an LMP1-induced STAT1 DNA-binding complex, different from that generated by alpha interferon (IFN) stimulation and not involving tyrosine phosphorylation, is demonstrated. STAT1 is serine-phosphorylated downstream of Pl3K and MEK in LCLs and this modification restricts IFN-stimulated STAT1 -DNA binding. These data suggest that EBV induces a distinct form of DNA-bound STAT1 in virus-infected cells.
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