Journal
ANALYTICAL CHEMISTRY
Volume 82, Issue 13, Pages 5887-5891Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ac902931x
Keywords
-
Categories
Funding
- Japan Science and Technology Agency
- Ministry of Education, Culture, Sports, Science and Technology
Ask authors/readers for more resources
We propose a novel strategy for determining the elemental composition of organic compounds using the peak ratio of isotopic fine structure observed by high-magnetic field Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR-MS). Using 3'-phosphoadenosine 5'-phosphosulfate and CTU guanamine as standard organic compounds, isotopic peaks derived from N-15-, S-34-, and O-18-substituted forms were separated from C-13-substituted species. Furthermore, these isotopic peaks were quantitatively detected and closely matched the natural abundance of each element. These data successfully led us to determine the one elemental composition in a standard independent manner. The approach should be particularly amenable to the metabolomics research field.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available