Journal
HAEMATOLOGICA
Volume 92, Issue 7, Pages 998-999Publisher
FERRATA STORTI FOUNDATION
DOI: 10.3324/haematol.10327
Keywords
Fc gamma R; single nucleotide polymorphism; rituximab; chemotherapy; diffuse large B-cell lymphoma
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Funding
- Croatian Ministry of Science [108007]
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We investigated the association of Fc gamma RIIIa and Fc gamma RIIa polymorphisms and response to R-CHOP in 58 patients with diffuse large B-cell lymphoma (DLBCL). Fc gamma RIIIa and Fc gamma RIIa polymorphisms did not influence response, event-free or overall survival. These results suggest that ADCC via Fc gamma RIIIa and Fc gamma RIIa may not be the major mechanism of activity of the R-CHOP combination in DLBCL.
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