Journal
EUROPEAN JOURNAL OF IMMUNOLOGY
Volume 37, Issue 7, Pages 1916-1923Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/eji.200737236
Keywords
BrdU; dynamics; germ-free; homeostasis; regulatory T cells
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Funding
- Intramural NIH HHS Funding Source: Medline
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CD25(+) regulatory T cells (Treg) are a heterogeneous population that exists as CD44(low) and CD44(high) cells. Here we report that while both CD44(low) and CD44(high) Treg are anergic and express similar levels of Foxp3, CD44(high) Treg are highly proliferative in vivo and are more potent suppressors in vitro than CD44(low) Treg. From analysis of the properties of Treg derived from germ-free mice, it was concluded that peptide antigens derived from intestinal microorganisms are not essential for the generation, in vivo proliferation or suppressive activity of Treg. Our results suggest that gut flora antigens play little or no role in the heterogeneity and homeostatic regulation of Treg.
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