Journal
JOURNAL OF NEUROIMMUNOLOGY
Volume 187, Issue 1-2, Pages 9-19Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jneuroim.2007.04.010
Keywords
matrix metalloproteinases; TIMPs; CNS plasticity; development; cognition; injury
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Funding
- NINDS NIH HHS [NS052580] Funding Source: Medline
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The matrix metalloproteinases (MMPs) are expressed in response to pro-inflammatory stimuli and other triggers. The MMPs cleave numerous substrates including extracellular matrix components, cytokines and growth factors. In the CNS, while most studied in the context of disease, the many physiological functions of the MMPs are now becoming appreciated. This review provides an overview of the growing body of evidence for physiological roles of MMPs both in CNS development and in CNS plasticity in normal brain functioning, including learning and memory, as well as in CNS repair and reorganization as part of the neuroimmune response to injury. (c) 2007 Elsevier B.V. All rights reserved.
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