Journal
ANALYTICAL CHEMISTRY
Volume 82, Issue 3, Pages 1138-1141Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ac902335e
Keywords
-
Categories
Funding
- Natural Science Foundation Project of Chongqing City [CSTC-2009BB5003]
- National Natural Science Foundation of China [20905062, 20675064]
- Southwest University [SWUB2008078]
- U.S. NIH [R01 EB002189, U01 AI075565]
- NSF [CHE 0506529]
Ask authors/readers for more resources
Reproducible electrochemically encoded quantum dot (QD) barcodes were prepared using the reverse-micelle synthetic approach. The encoding elements, Zn2+, Cd2+, and Pb2+, were confined within a single QD, which eliminates the cumbersome encapsulation process used by other common nanoparticle-based barcode preparation schemes. The distinct voltammetric stripping patterns of Zn2+, Cd2+ and Pb2+ at distinguishable potentials with controllable current intensities offer excellent encoding capability for the prepared electrochemical (EC) QDs. Additionally, the simultaneous modification of the QD barcode surface with organic ligands during the preparation process make them potentially useful in biomedical research. For proof of concept of their application in bioassays, the EC QD barcodes were further employed as tags for an immunoassay of a cancer marker, carcinoembryonic antigen (CEA). The voltammetric stripping response of the dissolved bardcode tags was proportional to log[CEA] in the range from 0.01 to 80 ng mL(-1), with a detection limit of 3.3 pg mL(-1). The synthesized EC QD barcodes hold considerable potential in biodetection, encrypted information, and product tracking.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available