Journal
EMBO REPORTS
Volume 8, Issue 7, Pages 644-650Publisher
WILEY
DOI: 10.1038/sj.embor.7401004
Keywords
endosome; ESCRT; MVB; ubiquitin; vesicle
Categories
Funding
- NIGMS NIH HHS [T32 GM007135, GM07135] Funding Source: Medline
Ask authors/readers for more resources
Targeting of ubiquitylated transmembrane proteins into luminal vesicles of endosomal multivesicular bodies (MVBs) depends on their recognition by endosomal sorting complexes required for transport (ESCRTs), which are also required for MVB vesicle formation. The model originally proposed for how ESCRTs function succinctly summarizes much of the protein-protein interaction and genetic data but oversimplifies the coordination of cargo recognition and cannot explain why ESCRTs are required for the budding of MVB vesicles. Recent structural and functional studies of ESCRT complexes suggest an alternative model that might direct the next series of breakthroughs in understanding protein sorting through the MVB pathway.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available