Journal
ARTIFICIAL ORGANS
Volume 31, Issue 7, Pages 500-508Publisher
BLACKWELL PUBLISHING
DOI: 10.1111/j.1525-1594.2007.00418.x
Keywords
artificial nerve conduit; bellows tube; bioabsorbable polymer; fibrin gel; peripheral nerve regeneration
Categories
Ask authors/readers for more resources
Nerve conduit tubes were developed using bioabsorbable polymer membranes, and the effects of tube shape-straight or bellows-shaped tubes-and the fibrin gel filling were investigated. The mechanical properties of the tubes were examined by in vitro tests, and their effectiveness for peripheral nerve regeneration was determined by grafting into experimentally transected sciatic nerves of rats. The bellows tube showed mechanically superior properties, and when used with the fibrin gel, it induced superior tissue formation of myelinated nerve fibers as compared to other tube types. The total area of myelinated axons regenerated in the fibrin-filled bellows tube was comparable to that of an isograft control, whereas those of the other tubes demonstrated inferior regeneration. This result suggests that the mechanically superior bellows tube filled with fibrin gel is an effective graft alternative for peripheral nerve regeneration.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available