Journal
EXERCISE AND SPORT SCIENCES REVIEWS
Volume 35, Issue 3, Pages 110-118Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/jes.0b013e3180a031ec
Keywords
central nervous system; cerebral blood flow; cerebral metabolism; hypoxia; mitochondria
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Under resting conditions, the brain is protected against hypoxia because cerebral blood flow increases when the arterial oxygen tension becomes low. However, during strenuous exercise, hyperventilation lowers the arterial carbon dioxide tension and blunts the increase in cerebral blood flow, which can lead to an inadequate oxygen delivery to the brain and contribute to the development of fatigue.
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