Journal
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
Volume 71, Issue 7, Pages 1807-1810Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1271/bbb.70245
Keywords
Bacillus mojavensis; ComX; posttranslational modification; quorum sensing; tryptophan
Categories
Funding
- NIGMS NIH HHS [R01 GM057720, GM57720] Funding Source: Medline
Ask authors/readers for more resources
Bacillus mojavensis strain RO-H-1 produces a post-translationally modified hexapeptide, the COMXRO-H-1 pheromone, that stimulates natural genetic competence controlled by quorum sensing. LC/ESI-MS analysis of partially purification of the ComX(RO-H-1) pheromone suggested a precise modification in its tryptophan residue. The corresponding COMXRO-H-1 pheromone prepared by solid-phase synthesis was identical to the natural pheromone, and showed significant biological activity. These results indicated that the posttranslational modification of the COMXRO-H-1 pheromone was geranylation on the tryptophan residue, resulting in the formation of a tricyclic structure. The COMXRO-H-1 pheromone was immediately dehydrated by acid because of its extreme acid lability.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available