Journal
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
Volume 58, Issue 3, Pages 325-331Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.diagmicrobio.2007.01.005
Keywords
candidemia; hospital; risk factors; incidence
Categories
Ask authors/readers for more resources
In recent decades, Candida spp. emerged as the fourth most common cause of nosocomial bloodstream infections. The incidence of candidemia was 0. 13 per 100 persons. Eighty-three cases (61 %) of candidemia were due to Candida albicans and 53 (39 %) to nonalbicans Candida spp. Twelve strains of Candida (9 %) had shown in vitro resistance to fluconazole, 5 (4 %) to itraconazole, 2 (1.5 %) to voriconazole, 12 (9 %) to 5-flucytosine, and 1 (0.7%) to amphotericin B. Multivariate logistic regression analysis of risk factors showed that length of hospitalization, presence of a central venous catheter, previous episodes of candidemia or bacteremia, parenteral nutrition, and chronic renal failure were variables independently associated with the development of candidemia. Multivariate logistic regression analysis of prognostic indicators showed that the independent variables associated with poor prognosis were inadequate initial therapy (P < .001) and high APACHE III score (P = .004). The inadequate initial therapy associated with mortality indicates the need for additional investigations to define high-risk patients for beneficial antifungal prophylaxis. (c) 2007 Elsevier Inc. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available