Journal
NANO LETTERS
Volume 7, Issue 7, Pages 2122-2128Publisher
AMER CHEMICAL SOC
DOI: 10.1021/nl071182z
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Funding
- NHLBI NIH HHS [HL083900] Funding Source: Medline
- NINDS NIH HHS [NS22764] Funding Source: Medline
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Biodegradable nanofibers have tremendous potential for tissue repair. However, the combined effects of nanofiber organization and immobilized bioactive factors on cell guidance are not well understood. In this study, we developed aligned and bioactive nanofibrous scaffolds by immobilizing extracellular matrix protein and growth factor onto nanofibers, which simulated the physical and biochemical properties of native matrix fibrils. The aligned nanofibers significantly induced neurite outgrowth and enhanced skin cell migration during wound healing compared to randomly oriented nanofibers. Furthermore, the immobilized biochemical factors (as efficient as soluble factors) synergized with aligned nanofibers to promote highly efficient neurite outgrowth but had less effect on skin cell migration. This study shed light on the relative importance of nanotopography and chemical signaling in the guidance of different cell behavior.
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