Journal
NATURE GENETICS
Volume 39, Issue 7, Pages 830-832Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ng2061
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Funding
- Medical Research Council [G0000934] Funding Source: Medline
- Wellcome Trust [068545/Z/02, 072029] Funding Source: Medline
- Medical Research Council [G0000934] Funding Source: researchfish
- MRC [G0000934] Funding Source: UKRI
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A genome- wide association scan in individuals with Crohn's disease by the Wellcome Trust Case Control Consortium detected strong association at four novel loci. We tested 37 SNPs from these and other loci for association in an independent case- control sample. We obtained replication for the autophagy- inducing IRGM gene on chromosome 5q33.1 ( replication P = 6.6 x 10(-4), combined P = 2.1 x 10(-10)) and for nine other loci, including NKX2- 3, PTPN2 and gene deserts on chromosomes 1q and 5p13.
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