Journal
MAGNETIC RESONANCE IMAGING
Volume 25, Issue 6, Pages 748-753Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.mri.2007.02.014
Keywords
T-2*; human brain; mapping; field strength
Funding
- Medical Research Council [G9900259] Funding Source: researchfish
- MRC [G9900259] Funding Source: UKRI
- Medical Research Council [G9900259] Funding Source: Medline
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Measurements have been carried out in six subjects at magnetic fields of 1.5, 3 and 7 T, with the aim of characterizing the variation of T-2* with field strength in human brain. Accurate measurement of T-2* in the presence of macroscopic magnetic field inhomogeneity is problematic due to signal decay resulting from through-slice dephasing. The approach employed here allowed the signal decay due to through-slice dephasing to be characterized and removed from data, thus facilitating an accurate measurement of T-2* even at ultrahigh field. Using double inversion recovery turbo spin-echo images for tissue classification, an analysis of T-2* relaxation times in cortical grey matter and white matter was carried out, along with an evaluation of the variation of T-2* with field strength in the caudate nucleus and putamen. The results show an approximately linear increase in relaxation rate R-2* with field strength for all tissues, leading to a greater range of relaxation times across tissue types at 7 T that can be exploited in high-resolution T-2*-weighted imaging. (c) 2007 Elsevier Inc. All rights reserved.
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