T2* measurements in human brain at 1.5, 3 and 7 T

Measurements have been carried out in six subjects at magnetic fields of 1.5, 3 and 7 T, with the aim of characterizing the variation of T-2* with field strength in human brain. Accurate measurement of T-2* in the presence of macroscopic magnetic field inhomogeneity is problematic due to signal decay resulting from through-slice dephasing. The approach employed here allowed the signal decay due to through-slice dephasing to be characterized and removed from data, thus facilitating an accurate measurement of T-2* even at ultrahigh field. Using double inversion recovery turbo spin-echo images for tissue classification, an analysis of T-2* relaxation times in cortical grey matter and white matter was carried out, along with an evaluation of the variation of T-2* with field strength in the caudate nucleus and putamen. The results show an approximately linear increase in relaxation rate R-2* with field strength for all tissues, leading to a greater range of relaxation times across tissue types at 7 T that can be exploited in high-resolution T-2*-weighted imaging. (c) 2007 Elsevier Inc. All rights reserved.