Journal
FOOD AND CHEMICAL TOXICOLOGY
Volume 45, Issue 7, Pages 1179-1185Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.fct.2006.12.026
Keywords
transgenic Bacillus thuringiensis; Vip3Aa7 protein gene; safety assessment; animal feeding studies
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The aim of this study was to evaluate the toxicology safety of a genetically modified (GM) Bacillus thuringiensis with vegetative insecticidal protein (VIP) gene. Acute and subacute toxicity studies by using its powder preparation were conducted in Wistar rats. The result of the acute study showed the no-observable-adverse-effect level (NOAEL) of this GM B. thuringiensis powder preparation was greater than 5000 mg/kg body weight (BW). In the subacute study, the data analysis of body weight gain, food and water consumptions, clinical observations, haematology, serum biochemistry, organ weight ratios and histopathological findings did not show significant differences between control and treated groups. These results proved the NOAEL of this GM B. thuringiensis powder preparation in subacute test was greater than 5000 mg/kg BW. Since both the acute and subacute oral toxicity were not detected at the highest dose recommended by OECD guidelines, this GM R thuringiensis could be generally regarded as safe for use in bio-pesticide industry. (c) 2007 Elsevier Ltd. All rights reserved.
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