Journal
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE
Volume 144, Issue 1, Pages 126-129Publisher
SPRINGER
DOI: 10.1007/s10517-007-0271-z
Keywords
human embryonic stem cells; chromosomes
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Cytogenetic analysis of karyotypes of hESM01-hESM04 human embryonic stem cells and substrains derived from these strains showed that all these strains retained normal karyotype during long-term culturing. Two substrains of embryonic stem cells with chromosome aberrations indicating clonal origin of these strains were detected. The potentialities of using analysis of chromosome variability of embryonic stem cells for evaluation of predisposition of the corresponding genotypes to the formation of chromosome abnormalities are discussed.
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