Journal
NEUROBIOLOGY OF DISEASE
Volume 27, Issue 1, Pages 99-101Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.nbd.2007.04.008
Keywords
Huntington's disease; mitochondria; electron transport system; platelets; human
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Funding
- NINDS NIH HHS [R01 NS041771-03, R01 NS050425-03, P01 NS035966-07S2, R01 NS041771-02, R01 NS041509-07, NS41771, P01 NS035966-07S1, P01 NS035966, R01 NS041771, R01 NS041771-04, R01 NS050425, R01 NS041509, R01 NS041771-01] Funding Source: Medline
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Two small case series of platelet mitochondrial complex I activity assays in Huntington's Disease (HD) report discrepant results. We measured platelet complex I and complex I/III activity in 21 subjects with early gene-positive HD and 14 age-matched controls. The 21 participants with HD that we studied are greater than the total of 16 in the two previously published of platelet ETS activity in HD. Reductions > 10% were excluded with 80% confidence. A systemic defect in complex I activity is not present in early HD when striatal neuronal degeneration is already present. (c) 2007 Elsevier Inc. All rights reserved.
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