Journal
ANALYTICAL CHEMISTRY
Volume 81, Issue 16, Pages 6744-6749Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ac900682f
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Funding
- Edgewood Chemical Biological Center (ECBC) Research and Technology Directorate
- Chemical Materials Agency
- Defense Threat Reduction Agency
- Joint Science and Technology Office (JSTO)
- DoD Chemical and Biological Defense Program
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Direct analysis in real time (DART) is an ion source that pen-nits rapid mass spectrometric detection of gases, liquids, and solids in open air under ambient conditions. It is a unique technology in the field of chemical weapons detectors in that it does not require a vapor pressure, does not require sample preparation, and is nondestructive to the original sample. While the DART technique has had success as a first line instrument of detection, there have been lingering doubts over the technique's quantitative reliability and reproducibility. Here, we demonstrate its capability to produce linear calibration curves (R-2 = 0.99 or better) for the nerve agents GA, GB, and VX as well as the blister agent HID. Independently prepared check standards measured against these curves typically have recovery errors less than 3%. We show the DART instrument response to be linear over roughly 3 orders of magnitude. Furthermore, this study shows that averaging as few as three measurements for each data point is sufficient to produce high quality calibration curves, thus reducing data collection time and providing quicker results.
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