Journal
SCHIZOPHRENIA RESEARCH
Volume 93, Issue 1-3, Pages 366-373Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.schres.2007.03.024
Keywords
schizophrenia; first-episode psychosis; P300 amplitude asymmetry; positive symptoms
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The amplitude of the P300 event-related potential (ERP) has been reported to be reduced over left compared to right temporal sites in schizophrenia patients. This left temporal P300 reduction has been associated with positive symptom severity and gray matter reduction in the left superior temporal gyrus. We investigated a group of patients with a first episode of schizophrenia spectrum psychosis and a group of normal controls to verify if P300 amplitude asymmetry already exists around the time of presentation for treatment. Relative to normal control subjects, no P300 asymmetry was found in patients. Nevertheless, P300 asymmetry was correlated with the severity of positive symptoms and worse global functioning (GAF), a good predictor of poor outcome. (c) 2007 Elsevier B.V. All rights reserved.
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