Journal
EXPERIMENTAL CELL RESEARCH
Volume 313, Issue 11, Pages 2318-2325Publisher
ELSEVIER INC
DOI: 10.1016/j.yexcr.2007.03.031
Keywords
Rab1; Rab6; GTPases; giantin; vesicular traffic; ER-Golgi transport
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The interaction of small GTPases of the Rab family and coiled coil proteins of the golgin family has been reported for example for the Rab1 GTPase and p115, GM130 and Giantin. We now show that Rab6A, a GTPase that controls retrograde trafficking within the Golgi back to the endoplasmic reticulum is also able to bind to Giantin in vivo and in vitro pointing to an interesting complex formation between Giantin and two different Rab GTPases. In Saccharomyces cerevisiae a genetic interaction between Ypt1 and Ypt6 has already been demonstrated, but in this paper we were able to describe that the mammalian Rab GTPases are able to interact on the same golgin protein, Giantin. (c) 2007 Elsevier Inc. All rights reserved.
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