Journal
BRITISH JOURNAL OF HAEMATOLOGY
Volume 138, Issue 2, Pages 249-252Publisher
WILEY
DOI: 10.1111/j.1365-2141.2007.06633.x
Keywords
monoclonal gammopathy of uncertain significance; autoimmune manifestations; immune thrombocytopenic purpura; thrombocytopenia; B-cell lymphoproliferative disorder
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Monoclonal gammopathy of uncertain significance (MGUS) may become symptomatic for autoimmune manifestations. We report on the prevalence and clinical course of immune thrombocytopenic purpura (ITP) observed in a consecutive series of 228 MGUS patients. At MGUS diagnosis, ITP was determined in 6/228 cases, accounting for a prevalence of 2630/100 000 [95% confidence interval (CI): 1210-5620]. One incidental ITP case occurred after 21 months of follow-up. After a follow-up of 681.3 patient-years, the crude incidence of ITP in MGUS was 146.8 per 100 000 patient-year (95% CI: 3.7-817.8). Overall, these observations point to an association between MGUS and ITP.
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