Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 17, Issue 1, Pages -Publisher
MDPI AG
DOI: 10.3390/ijms17010049
Keywords
spinal cord injury; curcumin; inflammation; cytokines; secondary processes; NF-kappa B
Funding
- GACR [13-15031P, 13-00939S]
- Kontakt II [LH12024]
- Norwegian Financial Mechanism
- MEYS [MSMT-28477/2014, 7F14057]
- European Regional Development Fund [CZ.1.05/1.1.00/02.0109]
Ask authors/readers for more resources
Well known for its anti-oxidative and anti-inflammation properties, curcumin is a polyphenol found in the rhizome of Curcuma longa. In this study, we evaluated the effects of curcumin on behavioral recovery, glial scar formation, tissue preservation, axonal sprouting, and inflammation after spinal cord injury (SCI) in male Wistar rats. The rats were randomized into two groups following a balloon compression injury at the level of T9-T10 of the spinal cord, namely vehicle-or curcumin-treated. Curcumin was applied locally on the surface of the injured spinal cord immediately following injury and then given intraperitoneally daily; the control rats were treated with vehicle in the same manner. Curcumin treatment improved behavioral recovery within the first week following SCI as evidenced by improved Basso, Beattie, and Bresnahan (BBB) test and plantar scores, representing locomotor and sensory performance, respectively. Furthermore, curcumin treatment decreased glial scar formation by decreasing the levels of MIP1 alpha, IL-2, and RANTES production and by decreasing NF-kappa B activity. These results, therefore, demonstrate that curcumin has a profound anti-inflammatory therapeutic potential in the treatment of spinal cord injury, especially when given immediately after the injury.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available