Journal
TRENDS IN CELL BIOLOGY
Volume 17, Issue 7, Pages 333-342Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tcb.2007.07.003
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Funding
- Biotechnology and Biological Sciences Research Council [BB/E016006/1] Funding Source: researchfish
- BBSRC [BB/E016006/1] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BB/E016006/1, C14770] Funding Source: Medline
- Wellcome Trust [063842] Funding Source: Medline
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Wnts are signalling molecules implicated in normal development and in disease. Although Writs can signal through three pathways, the canonical or beta-catenin pathway has been particularly studied because of its crucial role in embryonic patterning and cancer. It is well accepted that canonical Wnt signalling regulates gene expression by modulating the levels of beta-catenin, a co-activator of Tcf/Lef transcription factors. However, a divergent canonical Wnt pathway directly regulates the microtubulle cytoskeleton. Interestingly, many components of the pathway are associated with the cytoskeleton and can act locally. Here I discuss recent evidence supporting a direct role for canonical Wnt signalling in microtubule regulation, and how this function sheds a new light into the mechanisms that regulate cell-fate determination and polarization.
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