Journal
JOURNAL OF CLINICAL IMMUNOLOGY
Volume 27, Issue 4, Pages 347-362Publisher
SPRINGER/PLENUM PUBLISHERS
DOI: 10.1007/s10875-007-9084-0
Keywords
Mycobaterium tuberculosis; innate immunity; TLR2; dendritic cells; macrophages
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Funding
- NIAID NIH HHS [AI-55377, AI-49778] Funding Source: Medline
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This review focuses on recent progress in our understanding of Mycobacterium tuberculosis survival in macrophages, the interaction of M. tuberculosis with Toll-like receptors (TLRs) and the establishment of the link between innate and adaptive immunity, and TLRs and interferon-gamma-mediated antimicrobial pathways in macrophages. We also propose a paradigm that TLR2 signaling regulates the magnitude of the host Th1 response leading to either M. tuberculosis persistence and latent infection or replication and disease.
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