Journal
JOURNAL OF NUCLEAR CARDIOLOGY
Volume 14, Issue 4, Pages 521-528Publisher
MOSBY-ELSEVIER
DOI: 10.1016/j.nuclcard.2007.05.008
Keywords
myocardial perfusion single photon emission computed tomography; diagnosis; left main coronary artery disease
Ask authors/readers for more resources
Background. There have been limited data regarding the value of gated single photon emission computed tomography (SPECT) myocardial perfusion imaging (MPI) for the detection of left main coronary artery disease (CAD). Methods and Results. We studied 101 patients with angiographic left main CAD (>= 50% stenosis) and no prior myocardial infarction or coronary revascularization who underwent gated exercise or adenosine stress technetium 99m sestamibi SPECT MPI. By perfusion assessment alone, high-risk disease with moderate to severe defects (>10% myocardium at stress) was identified in only 56% of patients visually and 59% quantitatively. Absence of significant perfusion defect (>= 5% myocardium) was seen in 13% of patients visually and 15% quantitatively. However, by combining visual perfusion data and nonperfusion variables, especially transient ischemic dilation, 83% of patients were identified as high risk. Conclusions. The findings of this study demonstrate that assessment of perfusion data alone by visual or quantitative SPECT MPI analysis underestimates the magnitude of left main CAD. The combination of perfusion and nonperfusion abnormalities on gated MPI identifies high risk in most patients with left main CAD.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available