Journal
EPILEPSY RESEARCH
Volume 75, Issue 2-3, Pages 97-103Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.eplepsyres.2007.04.010
Keywords
gap junctions; all-trans retinoic acid; basotateral; amygdata; kindling
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Amygdala plays an important role in induction and control of limbic seizures. There is a network of gap junctional communications in basolateral amygdala (BLA) as well. We compared the effect of intra-BLA infusion of the typical gap junction (GJ) blocker carbenoxolone (CBX), with the effect of putative GJ blocker aR-trans retinoic acid (ATRA), on the afterdischarge (AD) recorded from BLA in amygdala-kindled rats. Both CBX and ATRA showed a rapid anti-seizure effect. Conversely, intra-BLA infusion of the known GJ opener, trimethylamine (TMA), enhanced seizure susceptibility by prolonging the duration of AD and generalized behavioral seizures. ATRA administered intra-BLA prevented the proconvulsant effect of TMA. The reduction of gap junctional conductance might be involved in the observed anticonvulsant effect of ATRA. (c) 2007 Elsevier B.V. All rights reserved.
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