Journal
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
Volume 454, Issue 4, Pages 523-533Publisher
SPRINGER HEIDELBERG
DOI: 10.1007/s00424-007-0238-y
Keywords
calcium; cytokines; T lymphocytes; transcription; NFAT; MEF2; DREAM
Categories
Ask authors/readers for more resources
The increase in intracellular calcium ion concentration is a general signaling mechanism used in many biological systems. In T lymphocytes, calcium is essential for activation, differentiation, and effector functions. In this study, we will summarize recent developments of how intracellular calcium concentrations are modified in T cells to affect the activity of three major calcium-dependent transcriptional effectors, i.e., NFAT, MEF2, and DREAM, involved in cytokine gene expression.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available